IVGTT glucose minimal model covariate selection by nonlinear mixed-effects approach

Epinephrine effects on insulin-glucose dynamics: the labeled IVGTT two-compartment minimal model approach.

The hyperglycemic effects of epinephrine (Epi) are established; however, the modulation of Epi-stimulated endogenous glucose production (EGP) by glucose and insulin in vivo in humans is less clear. Our aim was to determine the effect of exogenously increased plasma Epi concentrations on insulin and glucose dynamics. In six normal control subjects, we used the labeled intravenous glucose toleran...

Covariate Model Building in Nonlinear Mixed Effects Models

Assessment of the Oral Glucose Minimal Model by Nonlinear Mixed-effects Approaches

The oral minimal model (OMM) has been proposed and validated at individual level [1] to estimate after an oral glucose perturbation the rate of appearance of glucose (Ra) and the insulin sensitivity (SI). As commonly done in metabolic modeling, the OMM parameters are estimated by weighted nonlinear least square (WNLS) separately in each subject. Due to the complexity of the model, parameter pre...

A Particle Swarm Optimization Based Nonlinear Autoregressive Model for Predicting Plasma Glucose Level following Ivgtt

An important aspect of real time glucose control in diabetic subjects is forecasting the future glucose profile. From a modeling perspective, the complexity of interactions between plasma glucose and its controlling hormone insulin, demands a nonlinear modeling approach for representing the dynamics of glucose metabolism. In this paper, a technique based on the hybrid approach of nonlinear auto...

The hot IVGTT two-compartment minimal model: indexes  of glucose effectiveness and insulin sensitivity.

A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli. Am. J. Physiol. 264 ( Endocrinol. Metab. 27): E829-E841, 1993] to describe intravenous glucose tolerance test (IVGTT) labeled (hereafter hot) glucose kinetics. This model, at variance with the one-compartment minimal model (1CMM), allows the estimation of a plausible profile of glucose production. The aim of this...